p204 Protein Overcomes the Inhibition of Core Binding Factor -1–mediated Osteogenic Differentiation by Id Helix-Loop-Helix Proteins
نویسندگان
چکیده
*Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY 10003; §Department of Cell Biology, New York University School of Medicine, New York, NY 10016; †Institute of Pathogenic Biology, Shandong University School of Medicine, Jinan, Shandong 250012, China; and ‡State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
منابع مشابه
p204 protein overcomes the inhibition of core binding factor alpha-1-mediated osteogenic differentiation by Id helix-loop-helix proteins.
Id proteins play important roles in osteogenic differentiation; however, the molecular mechanism remains unknown. In this study, we established that inhibitor of differentiation (Id) proteins, including Id1, Id2, and Id3, associate with core binding factor alpha-1 (Cbfa1) to cause diminished transcription of the alkaline phosphatase (ALP) and osteocalcin (OCL) gene, leading to less ALP activity...
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The murine p204 protein level is highest in heart and skeletal muscle. During the fusion of cultured myoblasts to myotubes, the p204 level increases due to transcription dependent on the muscle-specific MyoD protein, and p204 is phosphorylated and translocated from the nucleus to the cytoplasm. p204 overexpression accelerates myoblast fusion in differentiation medium and triggers this process e...
متن کاملp204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins.
We reported in the accompanying article (Ding, B., Liu, C., Huang, Y., Hickey, R. P., Yu, J., Kong, W., and Lengyel, P. (2006) J. Biol. Chem. 281, 14882-14892) that (i) the p204 protein is required for the differentiation of murine P19 embryonal carcinoma stem cells to beating cardiac myocytes, and (ii) the expression of p204 in the differentiating P19 cells is synergistically transactivated by...
متن کاملId helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation.
Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE) induces osteoclast formation from monocyte/macrophage lineage cells via various transcription factors, including the Mi transcription factor (Mitf). Here, we show that inhibitors of differentiation/DNA binding (Ids), helix-loop-helix (HLH) transcription factors, negatively regulate TRANCE-induced osteoclast differentiation...
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INTRODUCTION Osteoclasts are derived from hematopoietic precursors in the presence of macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL). Binding of RANKL to its receptor RANK activates NF-κB, c-fos, and NFATc1, all of which are essential for osteoclastogenesis. The inhibitor of differentiation/DNA binding (Id), helix-loop-helix (HLH) proteins act as dom...
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